The science behind bright eyes.

With age, volume loss, sagging, and thinning of the skin can cause dark circles, shadows, and hollows under the eyes. These changes often make us look tired and older, even when well-rested and hydrated.

MACDERMOL® Under-Eye is designed to target these concerns, including tear trough hollows and fine lines. It fills depressions, thickens the skin, and reduces the appearance of visible blood vessels, helping to lighten dark circles.

Formulated with hyaluronic acid of the highest purity, it combines non-cross-linked and low chemically cross-linked HA. Its advanced X-Click technology minimizes the risk of migration and granuloma formation, ensuring safety and precision.

This filler integrates seamlessly with the delicate under-eye tissue, delivering smooth and balanced correction for a refreshed, bright, and awakened appearance.

The technology

Astagen Therapeutics® developed the innovative X-Click technology – a physical cross-linking method that uses no chemical agents, preserving biocompatibility, safety, and the natural properties of HA.

In Macdermol® Fine Lines, X-Click is combined with low chemically cross-linked HA to create a dual cross-linking system.

This approach enhances gel durability, ensures excellent tissue integration, provides a refined appearance, and significantly reduces the risk of migration and granuloma formation.

  • Protected from structural damages thanks to an optimized sterilization process, the HA in MACDERMOL® UNDER-EYE has an optimal average size in terms of beneficial effects on the extracellular matrix. 

  • Clinical data indicate thatMACDERMOL® UNDER-EYE has a lower rate of adverse events in comparison with other competitors.

Technical Informations

••• COMPOSITION: Non-animal hyaluronic acid. ¹

••• HA CONCENTRATION: 20 mg/ml

••• HA MOLECULAR WEIGHT: Between 3 and 4 millions Dalton

••• CROSS-LINKING: X-Click Technology + BDDE:

••• CROSS-RATE: ●●○○○

••• INDICATION: Reduces the appearance of the dark circles.

••• NEEDLE DIAMETER: 27 G

••• DURATION OF EFFECT: 6 to 9 months ²     

••• ADMINISTRATION: Linear threading technique into the submucosa of the lips.

••• PACKAGING: 1ml prefilled syringe.

¹ A version with 0,3% of lidocaine is also available on demand.

² Average duration depending on several factors such as patient's skin quality, patient's lifestyle, injection technique of the practitioner, and volume injected.