Smooths deep lines while preserving natural expression.

Macdermol® Deep Lines is indicated for patients who want to correct moderate to severe facial skin depressions such as nasolabial folds, marionette lines or concave scars.

This dermal filler is formulated with hyaluronic acid of the highest purity available in the industry, featuring a safe and effective dual cross-linking system that significantly reduces the risk of migration and granuloma formation. It also offers excellent tissue integration, allowing it to blend seamlessly with the skin’s natural structure.

The technology

Astagen Therapeutics® developed the innovative X-Click technology - A physical cross-linking method that uses no chemical agents, preserving biocompatibility, safety, and the natural properties of HA.

In Macdermol® Deep Lines, X-Click is combined with chemical cross-linking to create a dual cross-linking system.

This approach enhances gel durability, ensures excellent tissue integration, natural look and dramatically reduces the risk of migration and granuloma formation.

  • Protected from structural damages thanks to an optimized sterilization process, the HA in MACDERMOL® VOLUME has an optimal average size in terms of beneficial effects on the extracellular matrix. 

  • Clinical data indicate that MACDERMOL® VOLUME has a lower rate of adverse events in comparison with other competitors.

Technical Informations


••• COMPOSITION: Non-animal hyaluronic acid.

••• HA CONCENTRATION: 20 mg/ml

••• HA MOLECULAR WEIGHT: Between 3 and 4 millions Dalton

••• CROSS-LINKING: X-Click Technology + BDDE:

••• CROSS-RATE: ●●●●○

••• INDICATION: Correction of moderate to deep wrinkles.

••• NEEDLE DIAMETER: 27 G

••• DURATION OF EFFECT: 9 months on average.

••• ADMINISTRATION: Bolus or linear threading technique into the deep dermis.

••• PACKAGING: 1ml prefilled syringe.